The reference site for Protriptyline

Protriptyline (Vivactil) is a tricyclic antidepressant (TCA), specifically a secondary amine, indicated for the treatment of depression and ADHD.

WHAT IS PROTRIPTYLINE?

Protriptyline belongs to a class of similar drugs called tricyclic antidepressants. It is prescribed mainly to treat depression.

This medication may also be prescribed to treat attention deficit hyperactivity disorder (ADHD), narcolepsy, and along with several tricyclic antidepressants to reduce the incidence of recurring headaches such as migraines. While protriptyline was not developed specifically to treat these conditions, clinical trials sometimes indicate additional uses for a specific drug.

Protriptyline is sold under the brand name Vivactil®.

 

Brand Name(s): Vivactil
CAS nº: 438-60-8
(proe TRIP ti leen)

Product Info

The sections below will provide you with more specific information and guidelines related to protriptyline and its correct use. Please read them carefully.

FDA Information

Protriptyline was approved by the FDA in 1967. A prescription is required for this medicine.

On October 15th 2004, the FDA directed manufacturers of all antidepressants to include a Black Box warning, expanded warning statements, and clinical trial results detailing the increased risk of suicidality in children and adolescents. A Patient Medication Guide (MedGuide) will also accompany all prescriptions for antidepressants.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Protriptyline belongs to a class of drugs called tricyclic antidepressants, and is indicated mainly for the treatment of depression.

This medication may also be prescribed to treat attention deficit hyperactivity disorder (ADHD), narcolepsy, and along with other tricyclic antidepressants to reduce the incidence of recurring headaches such as migraines.

While protriptyline was not developed specifically to treat these conditions, clinical studies have shown additional uses for this drug.

Other uses for this medicine

This medication has not been approved for any alternative uses other than those mentioned in the product information section.

Dosage and using this medicine

Protriptyline comes as an oral tablet.

Protriptyline may be taken several times a day or in one daily dose (usually at bedtime). Take each dose with a full glass (8 ounces) of water.

Protriptyline is to be taken exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse or doctor to explain them to you.

It may be 4 weeks or more before you start to feel better, but do not stop taking protriptyline without first talking to your doctor.

What special precautions should I follow?

BEFORE TAKING PROTRIPTYLINE:

Tell your doctor if you have liver disease, kidney disease, asthma, thyroid disease, diabetes, stomach or intestinal problems, high blood pressure or heart disease, had a heart attack in the last 6 weeks, an enlarged prostate or difficulty urinating, or glaucoma. You may not be able to take protriptyline, or you may require a dosage adjustment or special monitoring during therapy if you have any of the conditions listed above.

While you are taking protriptyline you may need to be monitored for worsening symptoms of depression and/or suicidal thoughts at the start of therapy or when doses are changed. This concern about the increased risk of suicidal thoughts or behaviors may be greater if you are younger than 18 years of age and are taking protriptyline. For patients in this age group, the period of risk may extend beyond start of therapy or when doses are changed. Your doctor may want you to monitor for the following symptoms: anxiety, panic attacks, difficulty sleeping, irritability, hostility, impulsivity, severe restlessness, and mania (mental and/or physical hyperactivity). These symptoms may be associated with the development of worsening symptoms of depression and/or suicidal thoughts or actions. Contact your healthcare provider if you develop any new or worsening mental health symptoms during treatment with protriptyline.

On the other hand, do not stop taking this medicine suddenly. This could cause symptoms such as nausea, headache, and malaise.

Do not take protriptyline if you have taken a monoamine oxidase inhibitor such as isocarboxazid (Marplan®), phenelzine (Nardil®), or tranylcypromine (Parnate®) within the last 14 days.

Furthermore, this medicine may increase the effects of other drugs that cause drowsiness, including other antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any other prescription or over-the-counter medicines without first talking to your doctor.

Drugs other than those listed here may also interact with protriptyline. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Additionally, it is not known whether protriptyline will harm an unborn baby. Do not take protriptyline without first talking to your doctor if you are pregnant or could become pregnant during treatment.

Moreover, it is not known whether protriptyline passes into breast milk. Do not take protriptyline without first talking to your doctor if you are breast-feeding a baby.

If you are over 60 years of age, you may be more likely to experience side effects such as drowsiness, dizziness, unsteadiness, feeling uncoordinated, and low blood pressure. Your doctor may prescribe a lower dose of this medication.

Use cautiously when driving, operating machinery, or performing other hazardous activities. This medicine may cause drowsiness or dizziness, so try to avoid these activities.

Dizziness is likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.

Also, alcohol may increase drowsiness and dizziness while you are taking this medicine.

What should I do if I forget a dose?

Take the missed dose as soon as you remember. If, however, it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed.

It is strongly advised never to take a double dose of this medication unless otherwise directed by your doctor.

What side effects can this medication cause?

If you experience any of the following serious side effects, contact your doctor immediately or seek emergency medical treatment:

an allergic reaction (difficulty breathing, closing of the throat, swelling of the lips, face, or tongue, or hives)
seizures
a fast or irregular heartbeat
a heart attack
high blood pressure (blurred vision, severe headache)
difficulty urinating
fever with increased sweating
muscle stiffness, or severe muscle weakness

Other, less serious side effects may be more likely to occur. Continue to take protriptyline and talk to your doctor if you experience:

drowsiness or dizziness
dry mouth and eyes
constipation
mild tremor
sweating
mild agitation, weakness, or headache
ringing in the ears
nausea
loss of weight or appetite

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Remember to throw away any medication that is outdated or no longer needed. If you have any questions, please talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of a suspected overdose, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing, then please call the local emergency services immediately on 911.

Symptoms of an protriptyline overdose include:

seizures
confusion
drowsiness
agitation
hallucinations
low blood pressure (dizziness, fatigue, or fainting)

Product Images

PICTURES OF PROTRIPTYLINE PILLS

Below you will find images and specific information on the principal types of protriptyline that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

 

Name: VIVACTIL®
Strength(s): 10 MG
Imprint: 0P 702
Manufacturer: ODYSSEY

Name: VIVACTIL®
Strength(s): 10 MG
Imprint: MSD 47
Manufacturer: MERCK

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